Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma
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Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma.
Neuroblastoma (NB) is a paediatric tumour with a remarkable diverse clinical behaviour. Approximately half of the high stage aggressive tumours are characterized by MYCN gene amplification but our understanding of the role of MYCN in NB oncogenesis is incomplete. Previous studies have shown that MYCN expression is inversely correlated with expression of Dickkopf-3 (DKK3), a gene encoding an ext...
متن کاملMYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma.
The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the DKK family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in MYCN...
متن کاملMYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma
Running Title: Dickkopf-3 Regulating miRNAs in Neuroblastoma Authors with affiliations: Bjørn Helge Haug, Jørn Remi Henriksen, Jochen Buechner, Per Kogner, Tommy Martinsson, Trond Flægstad, Baldur Sveinbjørnsson, Christer Einvik Department of Pediatrics, University Hospital of North-Norway, 9038 Tromsø, Norway Pediatric Research Group, Department of Clinical Biology, Faculty of Health Science, ...
متن کاملThe miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks...
متن کاملmicroRNA-17 Is the Most Up-Regulated Member of the miR-17-92 Cluster during Early Colon Cancer Evolution
Deregulated microRNAs play a role in the development and progression of colon cancer, but little is known about their tissue and cell distribution in the continuum of normal mucosa through the premalignant adenoma to invasive adenocarcinoma. The aim of this study was to examine the expression pattern of the miR-17-92 cluster (miR-17, miR-18, miR-19, miR-20 and miR-92) as well as miR-21, miR-31,...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2011
ISSN: 0020-7136
DOI: 10.1002/ijc.26295